Experience-dependent rescaling of entorhinal grids

Nat Neurosci. 2007 Jun;10(6):682-4. doi: 10.1038/nn1905. Epub 2007 May 7.


The firing pattern of entorhinal 'grid cells' is thought to provide an intrinsic metric for space. We report a strong experience-dependent environmental influence: the spatial scales of the grids (which are aligned and have fixed relative sizes within each animal) vary parametrically with changes to a familiar environment's size and shape. Thus grid scale reflects an interaction between intrinsic, path-integrative calculation of location and learned associations to the external environment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Behavior, Animal
  • Brain Mapping
  • Entorhinal Cortex / cytology*
  • Male
  • Memory / physiology*
  • Models, Neurological
  • Neurons / physiology*
  • Orientation*
  • Photic Stimulation
  • Rats
  • Space Perception / physiology*