Exercise can prevent and even reverse adverse effects of androgen suppression treatment in men with prostate cancer

Prostate Cancer Prostatic Dis. 2007;10(4):340-6. doi: 10.1038/sj.pcan.4500975. Epub 2007 May 8.


Side effects accompanying androgen deprivation therapy (ADT), including sarcopenia, loss of bone mass and reduction in muscle strength, can compromise physical function, particularly in older patients. Exercise, specifically resistance training, may be an effective and cost-efficient strategy to limit or even reverse some of these adverse effects during and following therapy. In this review, we discuss common morphological and physiological ADT-related side effects or 'Androgen Deprivation and Sarcopenia-Related Disorders' and the existing clinical trials incorporating physical exercise in prostate cancer patients receiving active therapy. Further, training concepts and guidelines are provided for prescribing resistance exercise programs for this population.

Publication types

  • Review

MeSH terms

  • Androgen Antagonists / adverse effects*
  • Androgen Antagonists / therapeutic use
  • Exercise Therapy*
  • Humans
  • Male
  • Musculoskeletal Diseases / chemically induced
  • Musculoskeletal Diseases / therapy*
  • Prostatic Neoplasms / complications
  • Prostatic Neoplasms / drug therapy*
  • Treatment Outcome


  • Androgen Antagonists