Replication of hepatitis C virus

Nat Rev Microbiol. 2007 Jun;5(6):453-63. doi: 10.1038/nrmicro1645. Epub 2007 May 8.


Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps. These efforts have already translated into the identification of novel antiviral targets and the development of new therapeutic strategies, some of which are currently undergoing clinical evaluation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Hepacivirus / genetics
  • Hepacivirus / physiology*
  • Hepatitis C / virology
  • Humans
  • Viral Proteins / chemistry
  • Viral Proteins / physiology
  • Virus Cultivation / methods
  • Virus Internalization
  • Virus Replication*


  • Viral Proteins