Normal levels of serum IGF-I: determinants and validity of current reference ranges

Pituitary. 2007;10(2):129-33. doi: 10.1007/s11102-007-0035-9.


Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth hormone (GH) status. As a large number of determinants including age, gender, genetic factors, nutrition, and disease states influence IGF-I serum levels, accurate normative data are essential to translate patient data into diagnostic meaning or even use IGF-I levels for adequate monitoring of patients with an over- or under-active GH axis. Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I.

Publication types

  • Review

MeSH terms

  • Disease Susceptibility
  • Female
  • Human Growth Hormone / physiology
  • Humans
  • Insulin-Like Growth Factor I / analysis*
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / physiology
  • Insulin-Like Growth Factor I / standards*
  • Male
  • Reference Values
  • Reproducibility of Results


  • Human Growth Hormone
  • Insulin-Like Growth Factor I