Composition of the essential oil of Salvia officinalis L. from various European countries

Nat Prod Res. 2007 May;21(5):406-11. doi: 10.1080/14786410500528478.


Variations in the essential oil composition of Salvia officinalis L. growing in Estonia and in other European countries were determined. The oils were obtained in yields of 2.2-24.8 mL kg(-1). In three samples, the content of essential oil did not conform to the EP standard (10 mL kg(-1)). Variations in the essential oil composition of sage were studied using capillary gas chromatographic methods. A total of 40 components were identified. The principal components in the sage oils were 1,8-cineole, camphor, alpha-thujone, beta-thujone, borneol, and viridiflorol. The chemotypes of sage were not determined in investigated samples. The concentration of the main compounds in the drugs cultivated in Estonia varied in about the same range as the concentrations of these compounds in the oils of drugs obtained from other countries. The comparatively high concentration of toxic thujones seem to be characteristic to sage leaves cultivated in Estonia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bicyclic Monoterpenes
  • Camphor / chemistry
  • Chromatography, Gas
  • Cyclohexanols / chemistry
  • Estonia
  • Eucalyptol
  • Europe
  • Monoterpenes / chemistry
  • Oils, Volatile / chemistry*
  • Plant Oils / chemistry*
  • Salvia officinalis / chemistry*
  • Terpenes / chemistry


  • Bicyclic Monoterpenes
  • Cyclohexanols
  • Monoterpenes
  • Oils, Volatile
  • Plant Oils
  • Terpenes
  • Camphor
  • beta-thujone
  • Eucalyptol