Background: The wall of patent ductus arteriosus (PDA) in adults is usually fragile and may be associated with calcification.
Method: We present a 43-year-old female patient who underwent successful ductal closure operation under cardiopulmonary bypass (CPB) via a transpulmonary route.
Results: The operation was uneventful and the patient was discharged from the hospital on the 4th postoperative day.
Conclusion: Transpulmonary route for the closure of the PDA by using CPB is a safe and acceptable approach in adult patients.