Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle

Dev Cell. 2007 May;12(5):671-82. doi: 10.1016/j.devcel.2007.04.005.


Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Coatomer Protein / metabolism*
  • Humans
  • Protein Subunits / metabolism
  • SNARE Proteins / metabolism*
  • Transport Vesicles / metabolism*
  • rab GTP-Binding Proteins / metabolism*


  • Coatomer Protein
  • Protein Subunits
  • SNARE Proteins
  • rab GTP-Binding Proteins