Abstract
The activated partial thromboplastin time (aPTT) and anti-Xa activity are used for monitoring unfractionated heparin (UFH) therapy in children and may not be optimal.
Objective:
Determine correlations of aPTT, anti-Xa and UFH dose in children. Single centre prospective cohort study in children receiving UFH. The aPTT and anti-Xa results from routine coagulation monitoring were collected. Thirty-nine children (median age 18 days) were enrolled. There was no relationship between aPTT and UFH dose (r2=0.12) or anti-Xa and UFH dose (r2=0.03) or aPTT and anti-Xa (r2=0.22). aPTT and anti-Xa do not accurately monitor UFH therapy in children.
Publication types
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Comparative Study
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Evaluation Study
MeSH terms
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Adolescent
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Anticoagulants / administration & dosage*
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Anticoagulants / adverse effects
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Anticoagulants / pharmacology
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Anticoagulants / therapeutic use
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Blood Coagulation Tests*
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Child
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Child, Preschool
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Cohort Studies
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Critical Care / methods*
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Dose-Response Relationship, Drug
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Drug Monitoring
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Factor Xa Inhibitors*
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Female
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Heart Defects, Congenital / blood
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Hemorrhage / chemically induced
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Heparin / administration & dosage*
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Heparin / adverse effects
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Heparin / pharmacology
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Heparin / therapeutic use
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Humans
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Infant
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Infant, Newborn
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Male
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Partial Thromboplastin Time
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Postoperative Complications / prevention & control
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Prospective Studies
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Pulmonary Embolism / drug therapy
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Thrombin
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Thrombophilia / drug therapy
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Thrombosis / prevention & control
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Venous Thrombosis / drug therapy
Substances
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Anticoagulants
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Factor Xa Inhibitors
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Heparin
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Thrombin