It has been cogently argued that Web-based interventions hold substantial promise to deliver effective cessation to a wide audience. However, the potential effectiveness of a site is constrained by fundamental issues such as ease of navigation and structure of information, which impact a visitor's ability to find relevant information. Use of content and Web-design experts to assist in the development of cessation sites is a common approach. This approach, although highly useful, may fail to adequately identify problems that a more typical, target user would experience when visiting the site. Formal usability testing provides a user-centric approach to assessing a site's functionality. In this paper, we provide an example of this approach used in the development of a cessation Web site.