Genomic and functional evidence for an ARID1A tumor suppressor role

Genes Chromosomes Cancer. 2007 Aug;46(8):745-50. doi: 10.1002/gcc.20459.

Abstract

ARID1A is located in 1p36.11, a region frequently deleted in human cancers. Using a novel method to screen for tumorigenic cDNA sequences, we have identified ARID1A as a presumptive tumor suppressor gene. The transforming ARID1A sequence was an antisense cDNA, and was the product of a genomic rearrangement, as corroborated in the primary breast carcinoma from which the cDNA had been obtained. In further screening, we identified a lung adenocarcinoma cell line with a highly localized homozygous genomic deletion involving the 5' end of ARID1A. These studies provide strong evidence that ARID1A is a tumor suppressor gene. (c) 2007 Wiley-Liss, Inc.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 5' Flanking Region
  • Base Sequence
  • Breast Neoplasms / genetics
  • DNA, Antisense
  • DNA-Binding Proteins
  • Gene Deletion
  • Gene Rearrangement
  • Genes, Tumor Suppressor*
  • Humans
  • Lung Neoplasms / genetics
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology
  • Transcription Factors / genetics
  • Transcription Factors / physiology

Substances

  • ARID1A protein, human
  • DNA, Antisense
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Transcription Factors