Abstract
Endocannabinoid (eCB)-mediated forms of long-term synaptic plasticity occur in several brain regions, but much remains unknown about their basic properties and underlying mechanisms. Here, we present evidence that eCB-mediated long-term depression (eCB-LTD) at excitatory synapses on medium spiny neurons in the striatum requires presynaptic activity coincident with CB1 receptor activation. This dual requirement for CB1 activation and presynaptic activity is a mechanism by which eCB-LTD may be made synapse specific.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cannabinoid Receptor Modulators / metabolism*
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Cannabinoids / pharmacology
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism*
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Long-Term Synaptic Depression / drug effects
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Long-Term Synaptic Depression / physiology*
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Organ Culture Techniques
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Patch-Clamp Techniques
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Piperidines / pharmacology
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Presynaptic Terminals / drug effects
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Presynaptic Terminals / metabolism
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Pyrazoles / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptor, Cannabinoid, CB1 / agonists
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors
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Receptor, Cannabinoid, CB1 / metabolism*
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Synapses / drug effects
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Synapses / metabolism*
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
Substances
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Cannabinoid Receptor Modulators
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Cannabinoids
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Piperidines
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Pyrazoles
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Receptor, Cannabinoid, CB1
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AM 251