Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study

Obesity (Silver Spring). 2007 May;15(5):1082-8. doi: 10.1038/oby.2007.613.


We recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the risk of type 2 diabetes (T2D). Seven single nucleotide polymorphisms from two different haploblocks were genotyped from 507 participants of the Finnish Diabetes Prevention Study (DPS). Sex-specific genotype effects were observed. Three markers of haploblock 1 were associated with features of adiposity in women (rs5966709, rs4828037) and men (rs11798018). Markers rs2073163 and rs1155794 from haploblock 2 were associated with 2-hour plasma glucose levels in men during the 3-year follow-up. The same two markers together with rs2073162 associated with the conversion of IGT to T2D in men. The risk of developing T2D was approximately 2-fold in individuals with genotypes associated with higher 2-hour plasma glucose levels; the hazard ratios were 2.192 (p = 0.025) for rs2073162-A, 2.191 (p = 0.027) for rs2073163-C, and 1.998 (p = 0.054) for rs1155974-T. These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / genetics*
  • Diabetes Mellitus / prevention & control
  • Diet
  • Exercise
  • Female
  • Finland
  • Genotype
  • Glucose Intolerance / epidemiology
  • Glucose Tolerance Test
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Middle Aged
  • Obesity / epidemiology
  • Obesity / genetics*
  • Patient Selection
  • Polymorphism, Genetic*
  • Software


  • Membrane Proteins
  • TNMD protein, human