Reticulum cell sarcoma: two complete 'spontaneous' regressions, in response to high-dose ascorbic acid therapy. A report on subsequent progress

Oncology. 1991;48(6):495-7. doi: 10.1159/000226988.


In 1975, we reported the remarkable case of a 42-year-old man with histologically proven widely disseminated reticulum cell sarcoma who, in a remarkably short time, appeared to enjoy not one, but two, complete spontaneous regressions of his fatal illness. Both these regressions coincided exactly in time with intravenous high-dose ascorbate administration, and it seemed reasonable to conclude that this unconventional therapy must have been responsible for his excellent responses. For those interested in spontaneous regressions of cancer and the possible mechanisms, we now report his subsequent progress some 17 years later.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / complications
  • Ascorbic Acid / administration & dosage*
  • Dose-Response Relationship, Drug
  • Humans
  • Lymphoma, Non-Hodgkin / drug therapy*
  • Middle Aged
  • Neoplasm Regression, Spontaneous
  • Thyroid Neoplasms / complications


  • Ascorbic Acid