DoriC: a database of oriC regions in bacterial genomes

Bioinformatics. 2007 Jul 15;23(14):1866-7. doi: 10.1093/bioinformatics/btm255. Epub 2007 May 12.


Replication origins (oriCs) of bacterial genomes currently available in GenBank have been predicted by using a systematic method comprising the Z-curve analysis for nucleotide distribution asymmetry, DnaA box distribution, genes adjacent to candidate oriCs and phylogenetic relationships. These oriCs are organized into a MySQL database, DoriC, which provides extensive information and graphical views of the oriC regions. In addition, users can Blast a query sequence or even a whole genome against DoriC to find a homologous one. DoriC will be updated timely and the latest version is DoriC 1.8, in which oriCs of 425 genomes (468 chromosomes) are identified.

Availability: DoriC can be accessed from

Supplementary information: Supplementary data are available at

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Base Composition
  • Chromosome Mapping
  • Chromosomes, Bacterial
  • Computational Biology / methods*
  • Databases, Genetic
  • Databases, Nucleic Acid
  • Genome, Bacterial*
  • Internet
  • Phylogeny
  • Programming Languages
  • Replication Origin*
  • Software
  • Sulfolobus solfataricus / genetics