Variation in FTO Contributes to Childhood Obesity and Severe Adult Obesity

Nat Genet. 2007 Jun;39(6):724-6. doi: 10.1038/ng2048. Epub 2007 May 13.

Abstract

We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity*
  • Adult
  • Age of Onset
  • Body Composition
  • Body Mass Index*
  • Case-Control Studies
  • Child
  • Chromosomes, Human, Pair 16 / genetics*
  • Cohort Studies
  • Europe
  • Female
  • Genetic Predisposition to Disease*
  • Genetic Variation / genetics
  • Humans
  • Introns / genetics
  • Male
  • Middle Aged
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide / genetics*