Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients

Mediators Inflamm. 2007;2007:73635. doi: 10.1155/2007/73635. Epub 2007 Feb 25.

Abstract

This study compared lipids, the product of lipid peroxidation malondialdehyde (MDA), the acute phase reactant high-sensitive C-reactive protein (hsCRP), endothelin-1 (ET-1), P-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) between healthy controls, subjects with ischemic heart disease (IHD) and type 2 diabetes mellitus (DM) subjects who did not perform coronary artery bypass graft (CABG) surgery as well as type 2 DM subjects who performed CABG. HbA1c, lipids, MDA, hsCRP, ET-1, P-selectin, ICAM-1, and VCAM-1 levels were significantly higher in the diabetic groups than in either healthy controls or IHD subjects. In the diabetic groups, there was a negative association among hsCRP and HDL-C. ET-1, ICAM-1 levels, and TAG were positively correlated, as do the association between P-selectin, VCAM-1, and HbA1c%. Also a positive relation was found among hsCRP levels and ICAM-1, as well as MDA and ET-1. P-selectin and ICAM-1 were significantly positively correlated. This study indicates that increased level of oxidative stress marker, proinflammatory markers, and their downstream effectors adhesion molecules occur in type 2 DM.

MeSH terms

  • Adult
  • Analysis of Variance
  • C-Reactive Protein / metabolism*
  • Cell Adhesion Molecules / blood*
  • Cholesterol, HDL / blood
  • Coronary Artery Bypass
  • Diabetes Mellitus, Type 2 / blood*
  • Endothelin-1 / blood*
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • Male
  • Malondialdehyde / blood*
  • Middle Aged
  • Myocardial Ischemia / blood
  • Myocardial Ischemia / surgery
  • P-Selectin / blood
  • Triglycerides / blood
  • Vascular Cell Adhesion Molecule-1 / blood

Substances

  • Cell Adhesion Molecules
  • Cholesterol, HDL
  • Endothelin-1
  • P-Selectin
  • Triglycerides
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • Malondialdehyde
  • C-Reactive Protein