Animal models and vaccines for SARS-CoV infection

Virus Res. 2008 Apr;133(1):20-32. doi: 10.1016/j.virusres.2007.03.025. Epub 2007 May 11.

Abstract

We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Cricetinae
  • Disease Models, Animal*
  • Ferrets
  • Humans
  • Immunotherapy
  • Mesocricetus
  • Mice
  • Mice, Inbred C57BL
  • Primates
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / adverse effects
  • Recombinant Proteins / immunology
  • SARS Virus / immunology
  • SARS Virus / physiology
  • Severe Acute Respiratory Syndrome / immunology*
  • Severe Acute Respiratory Syndrome / prevention & control
  • Severe Acute Respiratory Syndrome / therapy
  • Severe Acute Respiratory Syndrome / virology
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / adverse effects
  • Vaccines, Inactivated / immunology
  • Viral Vaccines / administration & dosage*
  • Viral Vaccines / adverse effects
  • Viral Vaccines / immunology
  • Virus Replication

Substances

  • Recombinant Proteins
  • Vaccines, Inactivated
  • Viral Vaccines