Neurologic manifestations of the antiphospholipid syndrome

Curr Rheumatol Rep. 2007 May;9(2):109-15. doi: 10.1007/s11926-007-0004-3.


Antiphospholipid syndrome is an important cause of neurologic morbidity. The clinical criteria for antiphospholipid syndrome include only cerebrovascular arterial and venous thrombosis, but many other neurologic manifestations have been associated with antiphospholipid antibodies (aPL). This review discusses the role of aPL in cerebrovascular manifestations and in some of the other neurologic manifestations commonly associated with these antibodies, as well as data pertaining to the pathophysiology of aPL-associated neurologic manifestations and treatment issues.

Publication types

  • Review

MeSH terms

  • Antibodies, Phospho-Specific / blood*
  • Antiphospholipid Syndrome / complications*
  • Antiphospholipid Syndrome / diagnosis
  • Antiphospholipid Syndrome / immunology
  • Central Nervous System Diseases / diagnosis
  • Central Nervous System Diseases / etiology*
  • Central Nervous System Diseases / immunology
  • Humans
  • Venous Thrombosis / etiology
  • Venous Thrombosis / immunology
  • Venous Thrombosis / physiopathology


  • Antibodies, Phospho-Specific