Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine

Alummoottil V Joshua; Sanjay K Sharma; Alicia Strelkov; John R Scott; Mathew T Martin-Iverson; Douglas N Abrams; Peter H Silverstone; Alexander J B McEwan

doi:10.1016/j.bmcl.2007.04.069

Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4066-9. doi: 10.1016/j.bmcl.2007.04.069. Epub 2007 Apr 27.

Authors

Alummoottil V Joshua¹, Sanjay K Sharma, Alicia Strelkov, John R Scott, Mathew T Martin-Iverson, Douglas N Abrams, Peter H Silverstone, Alexander J B McEwan

Affiliation

¹ Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2. alummott@cancerboard.ab.ca

PMID: 17502140
DOI: 10.1016/j.bmcl.2007.04.069

Abstract

8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine, a potential D(4)-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism*
Clozapine / analogs & derivatives*
Clozapine / chemical synthesis
Clozapine / metabolism
Clozapine / pharmacokinetics
Mice
Rabbits
Receptors, Dopamine D4 / metabolism
Tissue Distribution

Substances

iozapine
Receptors, Dopamine D4
Clozapine