gyrA and parC Mutations and associated quinolone resistance in Vibrio anguillarum serotype O2b strains isolated from farmed Atlantic cod (Gadus morhua) in Norway

Antimicrob Agents Chemother. 2007 Jul;51(7):2597-9. doi: 10.1128/AAC.00315-07. Epub 2007 May 14.

Abstract

MIC testing of Vibrio anguillarum isolates recovered from diseased farmed Atlantic cod revealed oxolinic acid MICs of < or =0.001, 0.06, and 16 microg ml(-1). Single gyrA Ser-Ile substitutions were identified at position 83 of the intermediate and resistant strains, while a parC Ser-Leu substitution at position 85 was found only in the resistant strain.

MeSH terms

  • Animals
  • Base Sequence
  • DNA Gyrase / genetics*
  • DNA Topoisomerase IV / genetics*
  • Drug Resistance, Bacterial
  • Fish Diseases / microbiology
  • Fisheries
  • Gadus morhua / microbiology*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutation*
  • Norway / epidemiology
  • Quinolones / pharmacology*
  • Serotyping
  • Vibrio / classification
  • Vibrio / drug effects
  • Vibrio / enzymology
  • Vibrio / genetics*
  • Vibrio / isolation & purification
  • Vibrio Infections / drug therapy
  • Vibrio Infections / microbiology
  • Vibrio Infections / veterinary

Substances

  • Quinolones
  • DNA Topoisomerase IV
  • DNA Gyrase

Associated data

  • GDB/EF469668
  • GENBANK/DQ234973
  • GENBANK/DQ234978
  • GENBANK/EF469663
  • GENBANK/EF534721
  • GENBANK/EF534724