The Relationship of Dietary Lipid Intake and Age-Related Macular Degeneration in a Case-Control Study: AREDS Report No. 20

Arch Ophthalmol. 2007 May;125(5):671-9. doi: 10.1001/archopht.125.5.671.

Abstract

Objective: To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS).

Methods: Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N = 4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen).

Results: Dietary total omega-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal omega-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups.

Conclusion: Higher intake of omega-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Diet
  • Dietary Fats, Unsaturated / administration & dosage*
  • Energy Intake
  • Fatty Acids, Omega-3 / administration & dosage*
  • Feeding Behavior
  • Female
  • Humans
  • Macular Degeneration / prevention & control*
  • Male
  • Middle Aged
  • Models, Statistical
  • Odds Ratio
  • Surveys and Questionnaires

Substances

  • Dietary Fats, Unsaturated
  • Fatty Acids, Omega-3