Extended-wear silicone hydrogel soft contact lenses in the management of moderate to severe dry eye signs and symptoms secondary to graft-versus-host disease

Eye Contact Lens. 2007 May;33(3):144-7. doi: 10.1097/01.icl.0000244154.76214.2d.

Abstract

Purpose: To determine the safety and efficacy of the Focus NIGHT & DAY (CIBA Vision, Duluth, GA) silicone hydrogel contact lens in the management of refractory, moderate to severe dry eye signs and symptoms secondary to graft-versus-host disease (GVHD).

Methods: Seven patients with GVHD and moderate to severe dry eye disease as determined by the Ocular Surface Disease Index (OSDI) questionnaire were fitted with a near plano Focus NIGHT & DAY soft contact lens (SCL) used on a 7-night continuous-wear basis. Visual acuity, objective measures of dry eye disease (i.e., Schirmer I, tear breakup time, and corneal fluorescein staining), and OSDI scores were compared before SCL wear and after 1 week and 1 month of SCL wear.

Results: There was significant improvement in subjective assessment of dry eye symptoms (initial vs. 1-month OSDI score, 76.8 +/- 13.6 vs. 31.2 +/- 17.8, P<0.0005, paired t test). In addition, patients had significant improvement in best-corrected visual acuity after 1 month of SCL wear (initial vs. 1-month logMAR visual acuity for the right eye, 0.23 +/- 0.050 vs. 0.04 +/- 0.027, P<0.007; initial vs. 1-month logMAR visual acuity for the left eye, 0.22 +/- 0.049 vs. 0.04 +/- 0.020, P<0.007, analysis of variance, Dunnett post hoc). There were no significant changes in results of Schirmer I testing, corneal fluorescein staining, or tear breakup time. No adverse events or complications of SCL wear were observed.

Conclusions: The Focus NIGHT & DAY contact lens can improve subjective dry eye symptoms and visual acuity in patients with refractory dry eye disease secondary to GVHD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Contact Lenses, Extended-Wear*
  • Contact Lenses, Hydrophilic*
  • Cornea / metabolism
  • Dry Eye Syndromes / diagnosis
  • Dry Eye Syndromes / etiology*
  • Dry Eye Syndromes / physiopathology
  • Dry Eye Syndromes / therapy*
  • Female
  • Fluorescein
  • Fluorescent Dyes
  • Graft vs Host Disease / complications*
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Male
  • Middle Aged
  • Prospective Studies
  • Silicones
  • Staining and Labeling
  • Surveys and Questionnaires
  • Tears / metabolism
  • Treatment Outcome
  • Visual Acuity

Substances

  • Fluorescent Dyes
  • Silicones
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Fluorescein