Abstract
Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects
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Endothelial Cells / chemistry
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Endothelial Cells / drug effects
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Endothelial Cells / ultrastructure
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Endothelium, Vascular / chemistry
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Endothelium, Vascular / drug effects*
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Endothelium, Vascular / ultrastructure
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Genistein / pharmacology
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Glycine max / chemistry*
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Humans
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Isoflavones / pharmacology*
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Lipoproteins, LDL / antagonists & inhibitors*
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Lipoproteins, LDL / toxicity
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Mitochondria / chemistry
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Oxidation-Reduction
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Plant Extracts / pharmacology
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Proteome / analysis*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substances
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Isoflavones
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Lipoproteins, LDL
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Plant Extracts
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Proteome
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daidzein
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Genistein