Eosinophils and asthma

Curr Allergy Asthma Rep. 2007 Apr;7(1):18-26. doi: 10.1007/s11882-007-0026-y.


Recruitment and activation of eosinophils into the airways of asthma patients is suggested to be a contributing causative agent in the histopathologies and lung dysfunction that are characteristic of asthma. Recent studies in mouse models of asthma and in human patients implicate eosinophils in immune regulation and remodeling in the lung in addition to their hypothesized role as destructive agents. Specifically, eosinophils not only participate in release of granule proteins, lipid mediators, reactive oxygen species, cytokines, and growth factors but also function through complex cell-cell interactions to elicit chronic T helper 2 inflammation in the lung. This review highlights the roles of eosinophils in asthma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Asthma / etiology*
  • Asthma / therapy
  • Cell Communication
  • Cell Movement
  • Cell Survival
  • Cytokines / biosynthesis
  • Disease Models, Animal
  • Eosinophils / physiology*
  • Humans
  • Reactive Oxygen Species / metabolism


  • Cytokines
  • Reactive Oxygen Species