Centrosome biogenesis and function: centrosomics brings new understanding

Nat Rev Mol Cell Biol. 2007 Jun;8(6):451-63. doi: 10.1038/nrm2180.

Abstract

Centrosomes, which were first described in the late 19th century, are found in most animal cells and undergo duplication once every cell cycle so that their number remains stable, like the genetic material of a cell. However, their function and regulation have remained elusive and controversial. Only recently has some understanding of these fundamental aspects of centrosome function and biogenesis been gained through the concerted application of genomics and proteomics, which we term 'centrosomics'. The identification of new molecules has highlighted the evolutionary conservation of centrosome function and provided a conceptual framework for understanding centrosome behaviour and how it can go awry in human disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Cell Cycle / physiology*
  • Centrosome / metabolism*
  • Centrosome / ultrastructure
  • Cilia / metabolism
  • Cilia / ultrastructure
  • DNA Replication
  • Flagella / metabolism
  • Flagella / ultrastructure
  • Humans
  • Microtubule-Organizing Center / metabolism
  • Microtubule-Organizing Center / ultrastructure
  • Models, Biological