The "in vitro" antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans

Rev Inst Med Trop Sao Paulo. Mar-Apr 2007;49(2):93-5. doi: 10.1590/s0036-46652007000200005.


Cryptococcosis is a worldwide disease caused by the etiological agent Cryptococcus neoformans. It affects mainly immunocompromised humans. It is relatively rare in animals only affecting those that have received prolonged antibiotic therapy. The propolis is a resin that can present several biological properties, including antibacterial, antifungal and antiviral activities. The standard strain C. neoformans ATTC 90112 was used to the antifungal evaluation. The tests were realized with propolis ethanol extract (PEE) G12 in concentrations from 0.1 to 1.6 mg mL-1. The evaluation of MIC and MFC were done according to DUARTE (2002)5. The inhibitory effect of PEE G12 on the fungal growing was seen at the concentration of 0.2 mg mL-1 and 1.6 mg mL-1 was considered a fungicidal one.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Cryptococcus neoformans / drug effects*
  • Ethanol / pharmacology
  • Microbial Sensitivity Tests
  • Propolis / pharmacology*


  • Antifungal Agents
  • Ethanol
  • Propolis