microRNA functions

Annu Rev Cell Dev Biol. 2007;23:175-205. doi: 10.1146/annurev.cellbio.23.090506.123406.

Abstract

microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by translational inhibition and mRNA destabilization. Here, we review recent work in animal models that provide insight into the diverse roles of miRNAs in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Genetic Diseases, Inborn / genetics*
  • Humans
  • MicroRNAs / chemistry
  • MicroRNAs / metabolism
  • MicroRNAs / physiology*

Substances

  • MicroRNAs