Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti-inflammatory immuno-modulators?

FEBS Lett. 2007 Jul 31;581(19):3716-22. doi: 10.1016/j.febslet.2007.04.082. Epub 2007 May 8.


T cell responses to heat shock proteins (HSP) have disease suppressive activities through production of anti-inflammatory cytokines in patients and in models of inflammatory diseases. There is evidence that the anti-inflammatory activity of HSP-specific T cells depends on their recognition of endogenous HSP epitopes as expressed by stressed cells at sites of inflammation. Previously, we have demonstrated that such T cells can be induced by conserved sequences of microbial HSP. Now we propose that drug induced up-regulation of endogenous HSP can contribute to anti-inflammatory T cell regulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Heat-Shock Proteins / metabolism*
  • Humans
  • Immune System Diseases / immunology
  • Inflammation / immunology*
  • Mucous Membrane / immunology
  • NF-kappa B / antagonists & inhibitors
  • Rats
  • T-Lymphocytes, Regulatory / metabolism*
  • Up-Regulation


  • Anti-Inflammatory Agents
  • Heat-Shock Proteins
  • NF-kappa B