Clinical characteristics of exudative age-related macular degeneration in Japanese patients

Am J Ophthalmol. 2007 Jul;144(1):15-22. doi: 10.1016/j.ajo.2007.03.047. Epub 2007 May 23.


Purpose: To clarify the clinical characteristics of exudative age-related macular degeneration (AMD) in Japanese patients.

Design: Retrospective, observational, consecutive case series.

Methods: Two hundred and eighty-nine patients with neovascular AMD were examined.

Results: The authors classified the patients into three subtypes of neovascular AMD: polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), and typical AMD. One hundred and fifty-eight patients (54.7%) were diagnosed with PCV and 102 patients (35.3%) with typical AMD. RAP was observed in 13 patients (4.5%). In 16 patients (5.5%), one eye had PCV and the other eye had typical AMD. Most patients with PCV and typical AMD had unilateral disease (81.6% and 94.1%, respectively) with a male preponderance (77.8% and 71.6%, respectively). Nine of 13 patients with RAP were female (69.2%). Patients with RAP were older (mean, 80.3 years for men and 75.3 years for women) than patients with other subtypes. Serous and hemorrhagic pigment epithelial detachment developed in 69 patients (43.7%) with PCV, 22 patients (21.6%) with typical AMD, and nine patients (69.2%) with RAP. In the patients with unilateral disease in each subtype, large drusen in the unaffected eye were seen in 24.0% with PCV, 30.2% with typical AMD, and 77.8% with RAP.

Conclusions: Neovascular AMD in Japanese patients has different demographic features compared with that in White patients. In Japanese patients, there is a preponderance of PCV, male gender, unilaterality, and absence of drusen in the second eye, with the exception of RAP.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asians / ethnology
  • Choroid / blood supply
  • Choroid Diseases / diagnosis
  • Choroid Diseases / ethnology
  • Choroidal Neovascularization / diagnosis*
  • Choroidal Neovascularization / ethnology
  • Exudates and Transudates
  • Female
  • Fluorescein Angiography
  • Humans
  • Japan / epidemiology
  • Macular Degeneration / diagnosis*
  • Macular Degeneration / ethnology
  • Male
  • Peripheral Vascular Diseases / diagnosis
  • Peripheral Vascular Diseases / ethnology
  • Retinal Neovascularization / diagnosis
  • Retinal Neovascularization / ethnology
  • Retrospective Studies