Nuclear export and cytoplasmic maturation of ribosomal subunits

FEBS Lett. 2007 Jun 19;581(15):2783-93. doi: 10.1016/j.febslet.2007.05.013. Epub 2007 May 11.


Based on the characterization of ribosome precursor particles and associated trans-acting factors, a biogenesis pathway for the 40S and 60S subunits has emerged. After nuclear synthesis and assembly steps, pre-ribosomal subunits are exported through the nuclear pore complex in a Crm1- and RanGTP-dependent manner. Subsequent cytoplasmic biogenesis steps of pre-60S particles include the facilitated release of several non-ribosomal proteins, yielding fully functional 60S subunits. Cytoplasmic maturation of 40S subunit precursors includes rRNA dimethylation and pre-rRNA cleavage, allowing 40S subunits to achieve translation competence. We review current knowledge of nuclear export and cytoplasmic maturation of ribosomal subunits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Cytoplasm / metabolism
  • Models, Biological
  • Protein Subunits
  • RNA Precursors / chemistry
  • RNA Precursors / metabolism
  • RNA, Fungal / chemistry
  • RNA, Fungal / metabolism
  • RNA, Ribosomal / chemistry
  • RNA, Ribosomal / metabolism
  • Ribosomal Proteins / chemistry
  • Ribosomal Proteins / metabolism
  • Ribosomes / chemistry*
  • Ribosomes / metabolism*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / metabolism


  • Protein Subunits
  • RNA Precursors
  • RNA, Fungal
  • RNA, Ribosomal
  • Ribosomal Proteins
  • Saccharomyces cerevisiae Proteins