Abstract
From the whole plant of Ardisia japonica, four [1,4]benzoquinones were isolated by means of bioassay-directed fractionation of the EtOH extract. Apart from the two known compounds maesanin (1) and its congener 2, two new benzoquinones, i.e., 5-ethoxy-2-hydroxy-3-[(10Z)-pentadec-10-en-1-yl][1,4]benzoquinone (3) and 5-ethoxy-2-hydroxy-3-[(8Z)-tridec-8-en-1-yl][1,4]benzoquinone (4), were identified. All compounds showed significant in vitro bioactivities against the PTP1B enzyme, with IC50 values in the range of ca. 3-19 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ardisia / chemistry*
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Benzoquinones / isolation & purification
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Benzoquinones / pharmacology*
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Ethanol / chemistry
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Humans
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Inhibitory Concentration 50
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Protein Tyrosine Phosphatase, Non-Receptor Type 1
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Protein Tyrosine Phosphatases / antagonists & inhibitors*
Substances
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Benzoquinones
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Enzyme Inhibitors
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Ethanol
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PTPN1 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 1
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Protein Tyrosine Phosphatases