Gap junctions provide new links in left-right patterning

Néstor J Oviedo; Michael Levin

doi:10.1016/j.cell.2007.05.005

Gap junctions provide new links in left-right patterning

Cell. 2007 May 18;129(4):645-7. doi: 10.1016/j.cell.2007.05.005.

Authors

Néstor J Oviedo¹, Michael Levin

Affiliation

¹ The Forsyth Center for Regenerative and Developmental Biology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA.

PMID: 17512395
DOI: 10.1016/j.cell.2007.05.005

Abstract

Gap junctions are increasingly recognized as key regulators of embryonic development, nervous system function, and neoplasia. Chuang et al. (2007) now show that developing neural circuits use communication through gap junctions to establish left-right asymmetry in the central nervous system of the worm Caenorhabditis elegans, revealing that nematodes share a mechanism for left-right asymmetry in common with vertebrates.

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Body Patterning / physiology*
Caenorhabditis elegans / cytology
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / physiology
Calcium Signaling / physiology
Cell Differentiation / physiology
Functional Laterality / physiology*
Gap Junctions / physiology*
Gene Expression Regulation, Developmental / physiology
Nervous System / cytology
Nervous System / embryology*
Olfactory Pathways / cytology
Olfactory Pathways / embryology
Olfactory Pathways / physiology

Abstract

Publication types

MeSH terms

Grants and funding