PCNA, the Maestro of the Replication Fork

Cell. 2007 May 18;129(4):665-79. doi: 10.1016/j.cell.2007.05.003.

Abstract

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • DNA Repair / genetics
  • DNA Replication / genetics*
  • DNA-Binding Proteins / genetics
  • DNA-Directed DNA Polymerase / genetics
  • DNA-Directed DNA Polymerase / metabolism
  • Epigenesis, Genetic / genetics
  • Genomic Instability / genetics*
  • Humans
  • Proliferating Cell Nuclear Antigen / genetics*
  • S Phase / genetics*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Proliferating Cell Nuclear Antigen
  • DNA-Directed DNA Polymerase