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, 40 (12), 913-5

Use of an Interferon-Gamma Based Assay to Assess Bladder Cancer Patients Treated With Intravesical BCG and Exposed to Tuberculosis

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Use of an Interferon-Gamma Based Assay to Assess Bladder Cancer Patients Treated With Intravesical BCG and Exposed to Tuberculosis

M S Silverman et al. Clin Biochem.

Abstract

Objective: Compare the QuantiFERON-TB Gold In-Tube (QFT) assay and the tuberculin skin test (TST) in bladder cancer patients receiving high dose BCG therapy (BCG patients).

Design and methods: BCG patients and healthy visitors, both exposed to tuberculosis, were screened with a TST and QFT.

Results: QFT-TST correlation was excellent in visitors, but poor in BCG patients. BCG therapy predicted a positive TST (p<0.001) but not a positive QFT (p=0.35).

Discussion: The management of BCG patients was impacted, by measuring the QFT.

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