Gene essentiality, gene duplicability and protein connectivity in human and mouse

Trends Genet. 2007 Aug;23(8):375-8. doi: 10.1016/j.tig.2007.04.005. Epub 2007 May 21.


It has previously been found that, in yeast, gene essentiality is positively correlated with protein connectivity (number of interaction partners) but negatively correlated with the existence of gene duplicates and that highly connected proteins tend to have a low gene duplicability. Using data from human and mouse, we show here that, in mammals, the first of these relationships holds true, but unlike the second relationship in yeast, highly connected mammalian proteins tend to have a high gene duplicability, and there is no correlation between gene essentiality and gene duplication in mammals.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Duplication*
  • Genes, Essential*
  • Humans
  • Mice
  • Models, Biological
  • Proteins / genetics*
  • Proteins / metabolism
  • Proteomics
  • Yeasts / genetics


  • Fungal Proteins
  • Proteins