7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3840-4. doi: 10.1016/j.bmcl.2007.05.010. Epub 2007 May 10.


We report a new class of non-nucleoside antivirals, the 7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides, some of which possess remarkable potency versus a broad spectrum of herpesvirus DNA polymerases and excellent selectivity compared to human DNA polymerases. A critical factor in the level of activity is hypothesized to be conformational restriction of the key 2-aryl-2-hydroxyethylamine sidechain by an adjacent methyl group.

MeSH terms

  • Cytomegalovirus / enzymology*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Nucleic Acid Synthesis Inhibitors*
  • Pyridines / chemical synthesis
  • Pyridines / chemistry*
  • Pyridines / pharmacology
  • Structure-Activity Relationship


  • Enzyme Inhibitors
  • Nucleic Acid Synthesis Inhibitors
  • Pyridines
  • pyridine