Cleft anterior segment with maternal hypervitaminosis A

Br J Ophthalmol. 1991 Nov;75(11):691-2. doi: 10.1136/bjo.75.11.691.


We report a case of an 'hourglass' cornea and iris with reduplicated lens in the left eye of an infant girl. An excess of vitamin A products had been taken by the mother during pregnancy. Mechanisms by which vitamin A excess could have caused this are discussed.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Abnormalities, Multiple / chemically induced*
  • Adult
  • Cornea / abnormalities*
  • Female
  • Humans
  • Infant, Newborn
  • Iris / abnormalities*
  • Lens, Crystalline / abnormalities
  • Vitamin A / adverse effects*


  • Vitamin A