Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient

Clin Infect Dis. 2007 Jun 15;44(12):e118-20. doi: 10.1086/518282. Epub 2007 May 2.

Abstract

We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication. Administration of cidofovir followed by foscarnet was associated with total clearance of human herpesvirus 6 infection. Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Cidofovir
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use
  • Drug Therapy, Combination
  • Encephalitis, Viral / drug therapy*
  • Foscarnet / therapeutic use*
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Herpesvirus 6, Human / drug effects*
  • Herpesvirus 6, Human / pathogenicity
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / therapy
  • Male
  • Middle Aged
  • Organophosphonates / therapeutic use*
  • Roseolovirus Infections / drug therapy*
  • Roseolovirus Infections / etiology
  • Viral Load

Substances

  • Antiviral Agents
  • Organophosphonates
  • Foscarnet
  • Cytosine
  • Cidofovir