[Necrotizing myelopathy associated with neoplasia. A clinico-pathological study of 2 cases and a review of the literature]

An Med Interna. 1991 Oct;8(10):497-500.
[Article in Spanish]


Two cases of necrotic myelopathy are presented. This is a very rare paraneoplasic syndrome. One patient had clear cell renal carcinoma and other had lymphatic metastasis of malignant melanoma without filiation of the primary tumor. The complete spinal study (MNR, CT, myelography) proved normal. Diagnosis is possible when all other causes of spinal disease have been discarded. Nowadays, it is possible to diagnose this disease premortem. The international literature reviewed showed 31 cases published since 1903, associated mainly to malignant diseases such as lymphomas, lung cancer, renal carcinoma, breast cancer, leukemias, etc. The differential diagnosis appears in the comments, as well as the presentation and evolution of the cases described up until now.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Adenocarcinoma / pathology*
  • Adult
  • Carcinoma, Renal Cell / pathology*
  • Humans
  • Kidney Neoplasms / pathology*
  • Lymphatic Metastasis
  • Male
  • Melanoma / pathology*
  • Middle Aged
  • Myelitis / pathology*
  • Necrosis / pathology
  • Neoplasms, Unknown Primary / pathology*
  • Paraneoplastic Syndromes / pathology*