Mutation C11994T in the mitochondrial ND4 gene is not a cause of low sperm motility in Portugal

Fertil Steril. 2008 Mar;89(3):738-41. doi: 10.1016/j.fertnstert.2007.03.048. Epub 2007 May 22.


It has recently been suggested that a hitherto unobserved mutation, C11994T, causes oligoasthenozoospermia in men from India but at the same time does not affect systems other than the motility of the sperm. There are good reasons to question this proposition, in view of the worldwide mtDNA database and the Indian record in particular. We have further analyzed the oligoasthenozoospermic samples from a previous systematic study of infertile Portuguese men and found no instance of C11994T.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asthenozoospermia / enzymology
  • Asthenozoospermia / genetics*
  • Asthenozoospermia / physiopathology
  • DNA, Mitochondrial
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Mitochondria / enzymology*
  • Mutation*
  • NADH Dehydrogenase / genetics*
  • Oligospermia
  • Phenotype
  • Portugal
  • Sperm Motility / genetics*
  • Spermatozoa / enzymology*


  • DNA, Mitochondrial
  • NADH dehydrogenase subunit 4
  • NADH Dehydrogenase