Mutation C11994T in the mitochondrial ND4 gene is not a cause of low sperm motility in Portugal

Luísa Pereira; João Gonçalves; Hans-Jürgen Bandelt

doi:10.1016/j.fertnstert.2007.03.048

Mutation C11994T in the mitochondrial ND4 gene is not a cause of low sperm motility in Portugal

Fertil Steril. 2008 Mar;89(3):738-41. doi: 10.1016/j.fertnstert.2007.03.048. Epub 2007 May 22.

Authors

Luísa Pereira¹, João Gonçalves, Hans-Jürgen Bandelt

Affiliation

¹ Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.

PMID: 17517394
DOI: 10.1016/j.fertnstert.2007.03.048

Abstract

It has recently been suggested that a hitherto unobserved mutation, C11994T, causes oligoasthenozoospermia in men from India but at the same time does not affect systems other than the motility of the sperm. There are good reasons to question this proposition, in view of the worldwide mtDNA database and the Indian record in particular. We have further analyzed the oligoasthenozoospermic samples from a previous systematic study of infertile Portuguese men and found no instance of C11994T.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asthenozoospermia / enzymology
Asthenozoospermia / genetics*
Asthenozoospermia / physiopathology
DNA, Mitochondrial
Genotype
Haplotypes
Humans
Male
Mitochondria / enzymology*
Mutation*
NADH Dehydrogenase / genetics*
Oligospermia
Phenotype
Portugal
Sperm Motility / genetics*
Spermatozoa / enzymology*

Substances

DNA, Mitochondrial
NADH dehydrogenase subunit 4
NADH Dehydrogenase