Abstract
The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S1P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / administration & dosage
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Apoptosis
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Cyclophosphamide / administration & dosage
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Disease Models, Animal
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Female
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Injections, Intraperitoneal
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Lysophospholipids / metabolism*
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Ovarian Diseases / chemically induced
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Ovarian Diseases / metabolism
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Ovarian Diseases / prevention & control*
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Ovarian Follicle / metabolism*
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Ovarian Follicle / pathology
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Ovulation Induction
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Radiation Injuries, Experimental / etiology
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Radiation Injuries, Experimental / metabolism
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Radiation Injuries, Experimental / pathology
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Radiation Injuries, Experimental / prevention & control*
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Rats
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Rats, Wistar
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Sphingosine / analogs & derivatives*
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Sphingosine / metabolism
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Whole-Body Irradiation / adverse effects
Substances
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Antineoplastic Agents, Alkylating
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Lysophospholipids
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sphingosine 1-phosphate
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Cyclophosphamide
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Sphingosine