Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

Fertil Steril. 2008 Mar;89(3):732-5. doi: 10.1016/j.fertnstert.2007.03.065. Epub 2007 May 22.

Abstract

The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S1P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Apoptosis
  • Cyclophosphamide / administration & dosage
  • Disease Models, Animal
  • Female
  • Injections, Intraperitoneal
  • Lysophospholipids / metabolism*
  • Ovarian Diseases / chemically induced
  • Ovarian Diseases / metabolism
  • Ovarian Diseases / prevention & control*
  • Ovarian Follicle / metabolism*
  • Ovarian Follicle / pathology
  • Ovulation Induction
  • Radiation Injuries, Experimental / etiology
  • Radiation Injuries, Experimental / metabolism
  • Radiation Injuries, Experimental / pathology
  • Radiation Injuries, Experimental / prevention & control*
  • Rats
  • Rats, Wistar
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism
  • Whole-Body Irradiation / adverse effects

Substances

  • Antineoplastic Agents, Alkylating
  • Lysophospholipids
  • sphingosine 1-phosphate
  • Cyclophosphamide
  • Sphingosine