Oxidative Stress of Neural, Hematopoietic, and Stem Cells: Protection by Natural Compounds

Rejuvenation Res. 2007 Jun;10(2):173-8. doi: 10.1089/rej.2006.0515.

Abstract

During natural aging, adult stem cells are known to have a reduced restorative capacity and are more vulnerable to oxidative stress resulting in a reduced ability of the body to heal itself. We report here that the proprietary natural product formulation, NT020, previously found to promote proliferation of human hematopoietic stem cells, reduced oxidative stress-induced apoptosis of murine neurons and microglial cells in vitro. Furthermore, when taken orally for 2 weeks, cultured bone marrow stem cells from these mice exhibited a dose-related reduction of oxidative stress-induced apoptosis. This preclinical study demonstrates that NT020 can act to promote healing via an interaction with stem cell populations and forms the basis of conducting a clinical trial to determine if NT020 exhibits similar health promoting effects in humans when used as a dietary supplement.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Blueberry Plants / chemistry
  • Carnosine / pharmacology*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Cellular Senescence / drug effects
  • Cholecalciferol / pharmacology*
  • Dietary Supplements
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / drug effects*
  • Hematopoietic Stem Cells / metabolism
  • In Vitro Techniques
  • Mice
  • Mice, Inbred BALB C
  • Microglia / cytology
  • Microglia / drug effects*
  • Microglia / metabolism
  • Neurons / cytology
  • Neurons / drug effects*
  • Neurons / metabolism
  • Oxidative Stress / drug effects*
  • Plant Extracts / pharmacology*
  • Tea / chemistry

Substances

  • NT020 formula
  • Plant Extracts
  • Tea
  • Cholecalciferol
  • Carnosine