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, 96 (12), 1904-7

Further Observations on the Relationship Between the FGFR4 Gly388Arg Polymorphism and Lung Cancer Prognosis

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Further Observations on the Relationship Between the FGFR4 Gly388Arg Polymorphism and Lung Cancer Prognosis

A Matakidou et al. Br J Cancer.

Abstract

The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examined the relationship between genotype and overall survival. While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.

Figures

Figure 1
Figure 1
Kaplan–Meier curves for all lung cancer patients. Survival curves for the Gly/Gly homozygotes are shown as a solid line. The dashed line depicts the survival curve for the Gly/Arg heterozygotes, and the broken line depicts the survival curve for the rare homozygotes Arg/Arg.

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