Novel synthetic strategies for the preparation of prostacyclin and prostaglandin analogues--off the beaten track

Chem Commun (Camb). 2007 Jun 7;(21):2107-20. doi: 10.1039/b617693n. Epub 2007 Mar 14.

Abstract

The recent increase in activity in the fields of neuroscience and life sciences has been mirrored by the design and synthesis of novel chemically and metabolically stable prostaglandin and prostacyclin analogues. Consequently, convenient and practical access to these important classes of compounds is greatly coveted. Various strategies for the preparation of prostacyclin, prostaglandin and isoprostane analogues are discussed, with particular focus on novel approaches developed in our own laboratories.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epoprostenol / analogs & derivatives*
  • Epoprostenol / chemical synthesis*
  • Epoprostenol / chemistry
  • Molecular Structure
  • Prostaglandins, Synthetic / chemical synthesis*
  • Prostaglandins, Synthetic / chemistry

Substances

  • Prostaglandins, Synthetic
  • Epoprostenol