Stressing the role of FoxO proteins in lifespan and disease

Nat Rev Mol Cell Biol. 2007 Jun;8(6):440-50. doi: 10.1038/nrm2190.


Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of FoxOs is tightly regulated by post-translational modifications, including phosphorylation, acetylation and ubiquitylation. Several of the enzymes that regulate the turnover of these post-translational modifications are shared between FoxO and p53. These regulatory enzymes affect FoxO and p53 function in an opposite manner. This shared yet opposing regulatory network between FoxOs and p53 may underlie a 'trade-off' between disease and lifespan.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • Disease*
  • Forkhead Transcription Factors / classification
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism*
  • Glucose / metabolism
  • Humans
  • Life Expectancy*
  • Models, Biological
  • Protein Isoforms / classification
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism*
  • Protein Processing, Post-Translational
  • Tumor Suppressor Protein p53 / metabolism


  • Forkhead Transcription Factors
  • Protein Isoforms
  • Tumor Suppressor Protein p53
  • Glucose