Molecular regulation of angiogenesis and lymphangiogenesis

Nat Rev Mol Cell Biol. 2007 Jun;8(6):464-78. doi: 10.1038/nrm2183.


Blood vessels and lymphatic vessels form extensive networks that are essential for the transport of fluids, gases, macromolecules and cells within the large and complex bodies of vertebrates. Both of these vascular structures are lined with endothelial cells that integrate functionally into different organs, acquire tissue-specific specialization and retain plasticity; thereby, they permit growth during tissue repair or in disease settings. The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell-cell communication.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Blood Vessels / anatomy & histology
  • Blood Vessels / physiology
  • Cell Differentiation / physiology
  • Humans
  • Lymphangiogenesis / physiology*
  • Lymphatic Vessels / anatomy & histology
  • Lymphatic Vessels / physiology
  • Models, Biological
  • Neovascularization, Physiologic / physiology*


  • Biomarkers