Prospective study of coffee consumption and risk of Parkinson's disease

Eur J Clin Nutr. 2008 Jul;62(7):908-15. doi: 10.1038/sj.ejcn.1602788. Epub 2007 May 16.


Objective: To examine the prediction of coffee consumption on the incidence of Parkinson's disease.

Subjects and methods: The study population comprised 6710 men and women, aged 50-79 years and free from Parkinson's disease at the baseline. At baseline, enquiries were made about coffee consumption in a self-administered questionnaire as the average number of cups per day. During a 22-year follow-up, 101 incident cases of Parkinson's disease occurred. Parkinson's disease cases were identified through a nationwide registry of patients receiving medication reimbursement, which is based on certificates from neurologist.

Results: After adjustments for age, sex, marital status, education, community density, alcohol consumption, leisure-time physical activity, smoking, body mass index, hypertension and serum cholesterol, the relative risk for subjects drinking 10 or more cups of coffee per day compared with non-drinkers was 0.26 (95% confidence interval 0.07-0.99, P-value for trend=0.18). The association was stronger among overweight persons and among persons with lower serum cholesterol level (P-value for interaction=0.04 and 0.03, respectively).

Conclusions: The results support the hypothesis that coffee consumption reduces the risk of Parkinson's disease, but protective effect of coffee may vary by exposure to other factors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age Factors
  • Aged
  • Caffeine / adverse effects
  • Coffee / adverse effects*
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / etiology*
  • Parkinson Disease, Secondary / chemically induced*
  • Prevalence
  • Proportional Hazards Models
  • Prospective Studies
  • Registries
  • Risk Factors
  • Sex Factors
  • Surveys and Questionnaires


  • Coffee
  • Caffeine