Chronic myeloid leukaemia as a model of disease evolution in human cancer

Nat Rev Cancer. 2007 Jun;7(6):441-53. doi: 10.1038/nrc2147.


Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?

Publication types

  • Review

MeSH terms

  • Animals
  • Blast Crisis*
  • Cell Differentiation
  • Disease Progression*
  • Fusion Proteins, bcr-abl / physiology
  • Gene Expression Profiling
  • Genes, Tumor Suppressor / physiology
  • Genomic Instability
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
  • Models, Biological*
  • Neoplasms / pathology


  • Fusion Proteins, bcr-abl