Effects of octopamine on reproduction, juvenile hormone metabolism, dopamine, and 20-hydroxyecdysone contents in Drosophila

Arch Insect Biochem Physiol. 2007 Jun;65(2):85-94. doi: 10.1002/arch.20187.


The effect of an experimentally increased octopamine content (feeding flies with OA) on the levels of juvenile hormone (JH) degradation, dopamine (DA), and 20-hydroxyecdysone (20E) contents, oogenesis, and fecundity of wild type Drosophila flies has been studied. OA feeding of the flies was found to (1) cause a considerable decrease in JH degradation in females, but not males, of D. melanogaster and D. virilis; (2) have no effect on DA content in D. melanogaster and D. virilis; (3) increase 20E contents in D. virilis females; (4) decrease to a large extent the number of vitellogenic (stages 8-10) and mature (stage 14) oocytes in D. virilis; and (5) decrease the fecundity of D. melanogaster and D. virilis. A possible mechanism of action of OA as a neurohormone on the reproductive function of Drosophila is discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-Agonists / pharmacology*
  • Animals
  • Dopamine / analysis
  • Drosophila melanogaster / drug effects
  • Drosophila melanogaster / physiology
  • Drosophilidae / drug effects*
  • Drosophilidae / physiology
  • Ecdysterone / analysis
  • Female
  • Fertility / drug effects
  • Juvenile Hormones / analysis
  • Juvenile Hormones / metabolism
  • Male
  • Octopamine / pharmacology*
  • Oogenesis / drug effects*
  • Time Factors


  • Adrenergic alpha-Agonists
  • Juvenile Hormones
  • Octopamine
  • Ecdysterone
  • Dopamine