Abstract
In this issue of the European Journal of Immunology (EJI), Stewart et al. report about a population of gammadelta-T cells expressing an extensive repertoire of NK cell receptors, and the presence of non-rearranged germline TCRdelta transcripts in conventional NK cells. These findings and other recent studies highlight the similarities of NK cells and T cells and the problems in discriminating between these two lineages.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Animals
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Antigens, CD / metabolism
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Antigens, Surface / metabolism
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CD3 Complex / metabolism
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Cell Lineage / immunology
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Gene Rearrangement, T-Lymphocyte
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Humans
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Immunophenotyping
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Killer Cells, Natural / cytology
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / metabolism
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Lectins, C-Type / metabolism
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Mice
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NK Cell Lectin-Like Receptor Subfamily B
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Receptors, Antigen, T-Cell, gamma-delta / metabolism
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Receptors, Immunologic / analysis
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Receptors, Immunologic / metabolism
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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Antigens, CD
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Antigens, Surface
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CD3 Complex
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KLRB1 protein, human
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily B
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Receptors, Antigen, T-Cell, gamma-delta
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Receptors, Immunologic